Endocrine Abstracts

Introduction: Noonan syndrome is a genetic disorder that usually occurs on a sporadic basis (de novo mutuations) or with autosomal dominant inheritance. Patients present with dysmorphic facial features, cardiac disorders and short stature. Delay of puberty can also be noted. We present here an adult case of Noonan syndrome.Presentation: A 25 years old male presented to our department with low stature, decreased libido and absence of any secondary sexual ...

Introduction: Gonadal dysgenesis is a rare cause of primary amenorrhoea, and refers to a number of conditions in which gonadal development is abnormal leading to streak or hypoplastic gonads. We present a rare case of a girl with primary amenorrhea, tall stature, gonadal dysgenesis and karyotype 46,XX. A 15 years old girl with primary amenorrhoea referred to our department for futher investigation. On clinical examination she was tall (height 1.74 m), her weight was 76 kg and ...

Introduction: The management of schizophrenia involves drugs which inhibit domapine receptors. The drugs control the disease. However, they increase prolactin secretion and induce amenorrhea. The drugs induce the development of metabolic syndrome and as a result of obesity they may cause benign intracranial hypertension.Aim: The aim was to describe the case of a patient who developed schizophrenia and after therapy with antipsychotics benign intracranial...

IntroductionCorticosteroids are included in the maintenance immunosuppressive regimen in most kidney transplant recipients. Studies evaluating the effect of chronic low-dose glucocorticoid treatment on the hypothalamic-pituitary-adrenal (HPA) axis and the metabolic profile of these patients are limited.AimThe objective of the study was to evaluate the metabolic effects and the alterations of HPA axis regulati...

PurposeRadioactive iodine (RAI) is frequently used as adjuvant therapy in patients with differentiated thyroid cancer (DTC). However, its effect on ovarian reserve has not been fully elucidated, with studies yielding inconsistent results. The aim of this study was to systematically review and meta-analyze the best available evidence regarding the effect of RAI on ovarian reserve in premenopausal women with DTC.Methods<p class="...

IntroductionIn this study we present data on the long-term outcomes of treatment of patients with moderate and severe GO.Methods98 patients with GO attending our clinic for the last 13 years and received treatment for moderate to severe GO were evaluated for their long-term response to treatment. Initial decision for treatment was based on activity and severity of the disease, assessed by CAS-score and NOSPEC...

Background: Overshoot of weight regain following the treatment of hyperthyroidism is well described. Notwithstanding, there is a large interindividual variability in the observed weight changes. This study aims to identify parameters predicting excessive weight gain in hyperthyroidism patients.Methods: In a retrospective study of a prospectively completed database, we recruited consecutive patients with overt hyperthyroi...

Introduction: The SARS-CoV-2 virus has severely affected humanity. The disease causes pneumonia which may be severe. In many cases, patients, especially if there are comorbidities, may have a fatal outcome. The disease affects all organs and the variability of its manifestations has attracted intense scientific interest. Aim: The aim of the study was to describe the case of a patient who developed subacute thyroiditis after infection with the SARS-CoV-2 ...

Introduction: Researchers argue that increased morbidity is noted in pregnant women during the current COVID-19 pandemic. Reports indicate that the pandemic has led to disruptions in care of persons with diabetes. Glycated hemoglobin A1c (A1c) is not sufficient in screening for gestational diabetes mellitus (GDM) but may be of use in monitoring glycemia in GDM. To the best of our knowledge no studies honed on late pregnancy glycemia (via A1c), as a surrogate of the access/qual...

Background: Abdominal obesity is associated with insulin resistance and increased cardiometabolic disease risk, whereas lower-body fat accumulation seems protective against metabolic derangements. Differences in upper-body and lower-body adipose tissue (AT) function seem to underlie these opposing associations. Here, we investigated the inflammatory signature of upper- and lower-body AT in women with normal weight and obesity, as well as in human primary abdominal (ABD) and fe...